Saratov JOURNAL of Medical and Scientific Research

Nikishin D.V.

Penza State University Department of Human Anatomy, Assistant Professor, Candidate of Medical Science

Evaluation of the effectiveness of a resorbable membrane «Bio-Gidein» in combination with chitosan for the treatment of bone defects

Year: 2014, volume 10 Issue: №2 Pages: 239-245
Heading: Macro- and Micromorphology Article type: Original article
Authors: Kalmin O.V., Nikishin D.V., Volodina Yu.M.
Organization: Penza State University
Summary:

Objective: to evaluate the efficiency of a resorbable membrane «Bio-Gide» in combination with chitosan for guided bone regeneration during the degradation under the experimental conditions. Material and Methods. The histological methods provide the study of tissue samples from 6 adult rabbits from artificial mandible through 14, 28 and 42 days after surgery. In group 1 the treatment was carried out without the use of additional materials, by a blood clot. In group 2 closing of the damaged area was produced by xenopericardial plate «Bio-Gide» in combination with chitosan. Results. It has been established that the conduct of bone wound under a blood clot causes inflammatory response on the 14th day after the operation, to the 28th day inflammation disappears and it practically does not appear on the 42nd day. Closure of the bone defect using xenopericardial plate «Bio-Gide» with chitosan causes lesser inflammatory response. In the long-term period after the surgery inflammatory changes in the implantation can not be detected. Conclusion. Xenopericardial plate «Bio-Gide» in combination with chitosan has a positive impact on the recovery process of the bone defect. Neoplasm of bone occurs, the stage of development of cartilage is shortened. At the end of the experiment period xenopericardial plate is not detected indicating the high rate of its biodegradation.

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Morphological changes in bone tissue around titanium implants subjected to micro-arc oxidation in alkaline electrolytes with and without the use of «CollapAn-gel»

Year: 2013, volume 9 Issue: №4 Pages: 624-628
Heading: Macro- and Micromorphology Article type: Original article
Authors: Kalmin O.V., Rozen М.А., Nikishin D.V.
Organization: Penza State University
Summary:

The purpose of the article is to conduct comparative study of the features of reparative processes in the bone during installation of titanium implants with sandblasted exposed microarc subsequent oxidation in alkaline electrolyte using osteoinductive formulation without the use of this preparation. Material and Methods. Histologically examined tissue samples from 24 adult rabbits in the region of titanium implant with osteoinductive formulation and without after 7, 14, 28, 56 and 112 days postoperatively. Results. It has been revealed that the installation of titanium implants subjected to micro-arc oxidation in alkaline electrolytes without the use of osteoinductive preparation leads to a moderate inflammatory response and the processes of bone formation take more time. When using identical implants with osteoinductive preparation «CollapAn-gel» led to a less expressed inflammatory response and a more active process of bone formation. Conclusion. The use of titanium implants subjected to sandblasting followed microarc oxidation in alkaline electrolytes is optimally combined with osteoinductive agents as it provides the best clinical results and highlights shorter time of bone regeneration.

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