Evaluation of clinical efficacy of immunocorrection therapy for curing oral cavity candidosis

The research goal is to increase the efficacy of oral cavity candidosis treatment. 97 patients with oral cavity can-didosis have been examined and treated. Diagnostics of germ culture, microscopical investigation of smear of oral mucosa and the sensitivity determination of causal agents to antifungal drugs have been performed. In order to assess immunological status of patients the concentration of immunoglobulins in their saliva has been determined. In order to find out specific antibodies for yeast-like fungi immune-enzyme blood analysis has been used. All the patients have received complex treatment. The control group has been administered immunomodulator «Gepon» for application to oral mucosa. 64.8% of patients with chronic oral cavity candidosis have had low concentration of immunoglobulin G in their blood serum. The concentration of immunoglobulins IgA, IgG and IgM in oral fluid has been lower than normal. The treatment efficiency has been considered as a way of recovery of local immunological status. Local administration of «Gepon» has been proved to increase the treatment quality and remission period