Pathogenic specifics of articular cartilage metabolism regulation at the initial stage of gonarthrosis
Year: 2019, volume 15 Issue: №4 Pages: 939-943
Heading: Рathophysiology Article type: Original article
Authors: Puchinyan D.M., Gladkova E.V., Karyakina E.M., Belova S.V., Romakina N.A.
Organization: Saratov State Medical University
Heading: Рathophysiology Article type: Original article
Authors: Puchinyan D.M., Gladkova E.V., Karyakina E.M., Belova S.V., Romakina N.A.
Organization: Saratov State Medical University
Summary:
Objective: to clarify specifics of articular cartilage metabolism regulation in early stages of gonarthrosis. Material and Methods. 66 women aged 41 to 60 у. o. (median age 49 years; Q25%=44; Q75%=55) were examined. The control (n=30) and the main (n=36) groups were arranged depending on knee osteoarthritis clinical and instrumental presentations, or their absence. The levels of cartilage oligomeric matrix protein (COMP), acidic fibroblast growth factor (FGF-1), vascular endothelial growth factor (VEGF-A), interleukin-1 (3 (IL-1 (3) and superoxide dismutase-2 (SOD-2) in serum have been determined by solid-phase enzyme immunoassay. Results. There was a statistically significant increase in the level of COMP in blood serum as well as the increase in number and strengthening of negative correlation between cytokinesand SOD-2 in women of the main group. Conclusion. The increased content of COMP in blood serum and the rise in number of negative correlations between SOD-2 on the one hand, and COMP, IL-1 (3 and VEGF-A on the other may be early osteoarthritis presentations in the examined individuals.
Keywords: acidic fibroblast growth factor, interleukin-1β , osteoarthrosis of knee joint, superoxide dismutase-2 (SOD-2), vascular endothelial growth factor
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