Saratov JOURNAL of Medical and Scientific Research
Home

Comorbidity in patients with acute coronary syndrome in real (everyday) clinical practice

Year: 2019, volume 15 Issue: №3 Pages: 821-825
Heading: Cardiology Article type: Original article
Authors: Furman N.V., Dolotovskaya P.V., Malinova L.I., Reshetko O.V.
Organization: Saratov State Medical University
Summary:

The purpose of the study was to assess prevalence of comorbidity in the population of patients with acute coronary syndrome in Saratov region. Material and Methods. Inpatient and outpatient records of 484 patients with acute coronary syndrome (ACS) were analysed (64% of them residents of Saratov). Cases of cardiac and non-cardiac comorbidity were evaluated, Charlson Comorbidity Index (CCI) was calculated. Results. Only 20.5% of patients were without cardiac or non-cardiac comorbidity. Comorbid non-cardiac diseases were observed in 37.5% of patients (the most common diseases of the digestive system — 43% of all cases of non-cardiac comorbidity). Comorbid cardiovascular diseases were detected in 76.9% of patients, among the most common ones were arterial hypertension (88.4% of all cases of non-cardiac comorbidity) and documented hypercholesterolemia 42.2%). A correlation was found between the CCI and an unfavorable hospital outcome (0.227, P<0.0001). Conclusion. Patients with ACS in the vast majority of cases have at least one concomitant disease (cardiovascular or non- cardiac) that can significantly affect their prognosis. To determine individual prognosis for ACS patients with concomitant diseases, it is advisable to calculate the Charlson comorbidity index.

Keywords: acute coronary syndrome, Charlson Comorbidity Index, comorbidity, prognosis

Bibliography:
1 Oganov RG, Denisov IN, Simanenkov VI, et al. Comorbidities in practice: Clinical guidelines. Cardiovascular Therapy and Prevention 2017; 16 (6): 5-56. URL: http://dx.doi.Org/1 0.15829/1728-8800-2017-6-5-56
2 Oganov RG, Simanenkov VI, Bakulin IG, et al Comorbidities in clinical practice: Algorithms for diagnostics and treatment. Cardiovascular Therapy and Prevention 2019; 18 (1): 5-66. URL: http://dx.doi.org/10.15829/1728-8800-2019-1-5-66.
3 Murray MIK, Thalmann IN, Mossialos EA, Zeiher AM. Comorbidities of Coronary Heart Disease and the Impact on Healthcare Usage and Productivity Loss in a Nationally-Based Study. Epidemiology (Sunnyvale) 2018; 8: 347 DOI: 10.4172/2161 -1165.1000347.
4 Garcia-Olmos L, Salvador CH, Alberquilla A, et al. Comorbidity Patterns in Patients with Chronic Diseases in General Practice. PLoS ONE 2012; 7 (2): e32141. DOI: 10.1371/journal, pone. 32141
5 Kendir C, van den Akker M, Vos R, Metsemakers J. Cardiovascular disease patients have increased risk for comorbidity: A cross-sectional study in the Netherlands. Eur J Gen Pract 2018; 24 (1): 45-50. DOI:10.1080/13814788.2017.1 398318
6 Holden L, Scuffham PA, Hilton MiF, et al. Patterns of multimorbidity in working Australians Population Health Metrics 2011; 9: 15 DOI: 10.1186/1478-7954-9-15.
7 Buddeke J, Bots ML, van Dis I, et al. Trends in comorbidity in patients hospitalised for cardiovascular disease. Int J Cardiol 2017 Dec 1; 248: 382-8. DOI: 10.1016/j. ijcard. 2017.06.10.
8 Buddeke J, Bots ML, van Dis I, et al. Comorbidity in patients with cardiovascular disease in primary care: a cohort study with routine healthcare data. Br J Gen Pract 2019 Jun; 69 (683): e398-e406. DOI: 10.3399/bjgp19X702725.
9 Belyalov Fl. Twenty thesis of comorbidity. Clinical medicine 2009; 12: 69-71.
10 Forman DE, Maurer MS, Boyd С, et al. Multimorbidity in Older Adults with Cardiovascular Disease. J Am Coll Cardiol 2018; 71: 2149-61. URL: https://doi.Org/10.1016/j. jacc. 2018.03.022
11 McManus DD, Nguyen HL, Saczynski JS, et al. Multiple cardiovascular comorbidities and acute myocardial infarction: temporal trends (1990-2007) and impact on death rates at 30 days and 1 year. Clin Epidemiol 2012; 4: 115-23. DOI: 10.2147/CLEP S30883.
12 Efros LA, Lukin OP, Samorodskaya IV, et al. Comorbidities in patients with coronary artery disease admitted to cardiac surgery centers in Chelyabinsk and Kemerovo. Complex Issues of Cardiovascular Diseases 2017; 6 (4):
71-9. URL: https://doi.Org/1 0.17802/2306-1278-2017-6-4-71 -79 URL: https://doi.org/10.17802/2306-1278-201 7-6-4-71-79).
13 Barbarash NL, Semyonov VYu, Samorodskaya IV, et al. Comorbidity in coronary heart disease patients undergoing bypass grafting: an experience of two surgery centers. Russian Journal of Cardiology 2017; (3): 6-13. URL: https://doi.Org/10.1 5829/1560-4071-2017-3-6-13.
14 Charlson ME, Pompei Р, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987; 40 (5): 373-83. DOI: 10.1016/0021-9681 (87) 90171-8.
15 Myasoedova El, Schwarz YuG, Polunina OS, Voronina LP Influence of concomitant chronic obstructive pulmonary disease on left ventricular-arterial interaction in patients with ischemic cardiomyopathy. Russian Journal of Cardiology 2019; (2): 38-43. URL: https://doi.org/10.15829/1560-4071-2019-2-3 8-43
16 Savonitto S, Morici N, De Servic S. Treatment of Acute Coronary Syndromes in the Elderly and in Patients with Comorbidities. Rev Esp Cardiol 2014; 67 (7): 564-73. URL: http://dx.doi.Org/10.1016/j. rec. 2014.02.008
17 Khokhlova Yu. Comorbid status in acute coronary syndrome. Vrach (The Doctor) 2015; 3: 19-22.
18 Fassa А-А, Urban Р, Radovanovic D, et al. Impact of comorbidities on clinical presentation, management and outcome of patients with acute coronary syndrome. Cardiovascular Medicine 2010; 13: 155-61. DOI: 10.5167/uzh-36335
19 Radovanovic D, Seifert B, Urban P, et al. Validity of Charlson Comorbidity Index in patients hospitalised with acute coronary syndrome. Insights from the nationwide AMIS Plus registry 2002-2012. Heart 2014 Feb; 100 (4): 288-94 DOI: 10.1136/heartjnl-2013-304588.
20 Tisminetzky M, Gurwitz JH, Miozzo R, et al. Impact of cardiac- and noncardiac-related conditions on adverse outcomes in patients hospitalized with acute myocardial infarction. J Comorb 2019 May 28; 9: 2235042X19852499. DOI: 10.1177/2235042X19852499.

AttachmentSize
2019_03-1_821-825.pdf293.79 KB
All articles of the authors: Dolotovskaya P.V. , Furman N. V., Malinova L.I., Reshetko O.V.

No votes yet