Evaluation of retinal neuroarchitectonics in presence of optic nerve head drusen
Year: 2019, volume 15 Issue: №2 Pages: 490-494
Heading: Ophtalmology Article type: Review
Authors: Kabanova EA, Ioyleva EE, Zinovyeva AV.
Organization: Moscow State Medical Stomatological University n.a. A. I. Evdokimov, The S. Fyodorov Eye Microsurgery Federal State Institution
Heading: Ophtalmology Article type: Review
Authors: Kabanova EA, Ioyleva EE, Zinovyeva AV.
Organization: Moscow State Medical Stomatological University n.a. A. I. Evdokimov, The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:
Purpose: assessment of retinal neuroarchitectonics in presence of optic nerve head (ONH) drusen. Materials and Methods. 108 patients (216 eyes) with bilateral drusen of the optic disc aged 18–60 years were examined, and the control group consisted of 28 healthy subjects. All patients underwent optical coherence tomography (OCT) using Cirrus HD-OCT 5000–7544 device (Carl Zeiss Meditec Inc.). Results. Three types of ONH drusen localization relative to the Bruch membrane were identifed: superfcial, deep and difuse. Difuse localization of the drusen was determined in 48.6 % of cases, deep — in 40.3 %, superfcial — in 11.1 %. Deep optic disc drusen were more common in a young age (35.5±13.1 years), difuse — in medium age (42.0±13.2 years), superfcial — at an older age (51.7±12.8 years). With superfcial and difuse drusen of the optic disc, a signifcant (p<0.05) decrease in the thickness of the ganglion cell (GC) layer in all studied sectors, a decrease in the minimum and average GC thickness was found, as well as a signifcant (p<0.05) decrease in the average thickness and cubic volume of the neuroepithelium. With deep drusen opacities, the changes in GC were less pronounced and statistically insignifcant. Conclusion. analysis of the obtained data showed that deep drusen of the optic disc are the initial stage of congenital pathology, difuse drusen are a developed stage, and superfcial drusen of the optic disc characterize the development of fnal stage.
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