Saratov JOURNAL of Medical and Scientific Research

Ophthalmic medicinal films in the prevention of infectious and inflammatory complications

Year: 2018, volume 14 Issue: №4 Pages: 933-938
Heading: Ophtalmology Article type: Review
Authors: Aznabaev М.Т., Azamatova G.A., Gaysina G.Ya.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

This review focuses on prolonged dosage form — ophthalmic medicinal films. The composition, method of manufacturing the main eye films used in ophthalmology, the mechanism of prolongation of the immobilized drug substance are considered. The evacuation of the antibiotic from the polymer matrix, the pharmacokinetics of the drug, the therapeutic effect of the use of films was studied. When using eye films with an antibiotic in the chamber moisture of the eye, a therapeutically effective concentration of the drug substance is created and maintained for a long time. Ophthalmic medicinal films have significant advantages over the widely used methods of preoperative prevention of infection complications. Of great interest are eye films with fluoroquinolones based on a polysaccharide-modified matrix. Developed ophthalmic medicinal films have, in addition to the specific biological effects of an effective antibiotic, additional desired properties. The most promising forms of eye films for the prevention and treatment of intraocular infection are highlighted.

Bibliography:
1 Kazajkin VN, Ponomarev VO, Takhchidi HP. Modern Aspects of the Treatment of Acute Bacterial Postoperative Endophthalmitis. Ophthalmology in Russia 2017; 14 (1): 12-7
2 Barry Р, Cordoves L, Gardner S. ESCRS Guidelines for Prevention and Treatment of Endophthalmitis Following Cataract Surgery. Co Dublin: Temple House, Temple Road, Blackrock, 2013; p. 7-13
3 Assaad D, Wong D, Michail M, et al. Bacterial endophthalmitis: 10-year review of the culture and sensitivity patterns of bacterial isolates. Can J Ophthalmol 2015; 50 (3): 433-40
4 Aznabaev MT, Azamatova GA, Avhadeeva SR, et al. Modern methods of antibiotic prophylaxis of intraocular infection in cataract surgery. Practical medicine 2011; 2 (49): 134-7
5 Aznabaev MT, Azamatova GA. Method of prevention intraocular infections after cataract phacoemulsification by means of levofloxacin ophthalmic medicinal films. Bulletin of the Orenburg State University 2010; (12): 8-10
6 Gavrilova TV, Subbotina IN, Mukhamadeeva SN, et al. Modern approaches to the treatment of postoperative complications in cataract and glaucoma surgery. In: VII Euro-Asian Conference on Ophthalmic Surgery"Controversial issues of modern ophthalmic surgery" 2015; (1): 12-3
7 Gaysina GYa. The rationale for the use of ophthalmic medicinal films with moxifloxacin: PhD abstract. St. Petersburg, 2016; 24 p.
8 Danilichev VF. Modern ophthalmology. St. Petersburg: Piter, 2009; 688 p.
9 Freidlander М, Breshears D, Amoozgar В. The dilution of benzalkonium chloride (ВАК) in the tear film. Advances in Therapy 2006; 23: 835-41
10 Egorov EA, Astakhov US, Stavitskaya TV. Ophthalmopharmacology. Moscow: Geotar-Media, 2009; 469 p.
11 Davydov АВ, Mikhaylov SF. Development of a highly effective method for the treatment of a wide range of diseases, the creation and introduction into medical practice of new therapeutic agents — medicinal films and medical products based on biocompatible polymers. Moscow: Inpolimed, 2010; 95 p.
12 Montan Р, Lundstrom М, Stenevi U. Endophthalmitis following cataract surgery in Sweden: The 1998 National prospective survey. Acta Ophthalmol Scand 2002; 80 (3): 258-61
13 Stephen S, Robert H, Samuel S, et al. Evaluation of the safety of prophylactic intracameral moxifloxacin in cataract surgery. J Cataract Refract Surg 2008; (34): 1451-9
14 Mamalis N. Toxic anterior segment syndrome update. J Cataract Refract Surg 2010; 36 (3): 1067-8
15 Alekperov SI. Justification of the use of therapeutic soft contact lenses, saturated with drugs, in the system of medical-evacuation measures of the Russian Federation: PhD abstract. St. Petersburg, 2013; 22 p.
16 Boyko EV, Fokina DV, Reytuzov VA, et al. The comparison of different drug delivery methods of levofloxacin in the anterior chamber. Ophthalmological statements 2013; 6 (2): 25-9
17 Maychuk UF. Materials jubilee scientific and practical conference of ophthalmologists of the city of Moscow 1967; 403-5
18 Davydov АВ. Prospects for the use of polymeric materials and products in medicine. In: Abstracts of the report I Congress VNMTO 1975; 139-42
19 Erichev VP Ophthalmic medicinal films in the treatment of primary glaucoma: PhD abstract. Moscow, 1982; 17 p.
20 Khlusov IA, Chuchalin VS, Khoruzhaya TG. The establishment and functioning of drug delivery systems. Tomsk: Publishing house of Tomsk Polytechnic University, 2008; 81 p.
21 Maychuk UF, Khromov GL. About kanamycin ophthalmic medicinal films. Bulletin of Ophthalmology 1977; (6): 61-2
22 Erofeeva LN. Medicinal films: history and modernity. In: Materials of the International Scientific Conference dedicated to the 83rd anniversary of KSMU 2018; (2): 52-7
23 GendrolisAU. Eye dosage forms in pharmacy. Moscow: Meditsina, 1988; 256 p.
24 Maychuk UF, Yuzhakov AM. Ocular medicinal films: long-term results and application prospects. Medical equipment 1994; (2): 34-6
25 Nuritdinov VA. Polyacrylamide as the basis of ocular drug films. Bulletin of Ophthalmology 1981; (2): 59-60
26 Orlovskaya LE, Buzukina LP, Abiodun L. Experimental study of dexamethasone ophthalmic medicinal films. Pathophysiology and biochemistry of the eye 1986; (1): 79-83
27 Yuzhakov AM, Maychuk UF, Gundorova RA. Prevention of intraocular infection in ophthalmology using medicinal films with antibacterial agents. In: Materials of the I Congress of Ophthalmologists of Kazakhstan 1977; (1): 27-8
28 Batyrbekov ЕО, Utelbaeva ZT, Umerzakova MB, et al. Release of drugs from polymeric ophthalmic films. Basic research 2011; (7): 233-4
29 Badykova LA, Azamatova GA, Mudarisova RK. Intrapolymer film as a prolonged ophthalmic dosage form.Chemistry and Medicine 2010; (1): 116-8
30 Azamatova GA. Experimental substantiation of the method of prevention of infection complications of cataract surgery: PhD abstract. Krasnoyarsk, 2011; 23 p.
31 Aznabaev МТ, Gaysina GY, Azamatova GA, et al. Assesment of the effectiveness of preoperative methods of antibiotic prophylaxis in ophtalmic surgery. Medical Bulletin of Bashkortostan 2015; 10 (2): 85-8
32 Guillard Т. Fluoroquinolones Resistance Mechanisms and population structure of Enterobacter cloacae non susceptible to Ertapenem in North-Eastern France. Front Microbiol 2015; 23 (6): 1186.

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