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Correction of the dry eye syndrome of professional etiology using a complex of mitochondrial substrates and co-factors

Year: 2018, volume 14 Issue: №4 Pages: 799-804
Heading: Ophtalmology Article type: Original article
Authors: Anisimova S.G., Mazina N.K., Abramova T.V.
Organization: Kirov Regional Clinical Hospital, Kirov State Medical University
Summary:

Aim: to evaluate the effect of the drug Cytoflavin (CFL), containing mitochondrial substrates and co- factors, on tear production in arc welders, gas welders and office workers with dry eye syndrome (DES). Material and Methods. 124 patients (248 eyes) with DES of professional etiology were enrolled in this study. Patients of the experimental group (CFL) took three 25-day courses of cytoflavin separated by 1 month intervals, while the control group received placebo. Results. Reception of CFL over 3-month cycles with intervals of 30 days contributed to an increase in visual acuity (VA) by 29,0-34,0%, Schirmer's test (ST) by 27.0-51.0%, and Norn's test (NT) by 7.5-11.0%, meniscus measurements (MM) by 32.0-37.0% and lower indices of intraocular pressure (IOP) by 3-5% in both occupational groups. Conclusion. The resulting increase in values of parameters characterizing the functional activity of the lacrimal gland under the action of the CFL suggest that pharmacological energy protection contributes to the improvement of tear production and eye hydrodynamics in welders and office workers.

Keywords: dry eye syndrome, mitochondria, succinic acid, treatment

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All articles of the authors: Abramova T.V. , Anisimova S.G., Mazina N.K.

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