Saratov JOURNAL of Medical and Scientific Research

The state of the hemocoagulation system and endothelial dysfunction in benign and malignant skeleton neoplasms

Year: 2018, volume 14 Issue: №3 Pages: 574-578
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Ponamarev I.R., Puchinyan D.M., Gladkova E.V., Korshunov G.V.
Organization:
Summary:

Aim: to study the functional status of the vascular endothelium and the activity of the hemocoagulation system, as well as the relationship between some indicators characterizing their state in patients with benign and malignant skeleton neoplasms. Material and Methods. 62 patients with benign (45) and malignant (17) bone neoplasms and 10 healthy individuals of the control group were examined. The coagulation properties of blood plasma and the content of vascular endothelial growth factor (VEGF), intercellular adhesion molecules of sICAM and adhesion molecules of vascular endothelium (sVCAM) in blood serum were investigated. Results. In patients with benign bone tumors, prothrombinase formation mechanisms were activated, the concentration of soluble fibrin-monomer complexes (FSC) was

Bibliography:
1 Khorana AA. Venous thromboembolism and prognosis in cancer. Thromb Res 2010; 125 (6): 490-3
2 Кузник Б. И. Клеточные и молекулярные механизмы регуляции системы гемостаза в норме и при патологии. Чита: Экспресс-издательство, 2010; 832 с.
3 Donnellan Е, Khorana AA. Cancer and Venous Thromboembolic Disease: A review. Oncologist 2017; 22 (2): 199-207
4 Patell R, Gutierrez A, Rybicki L, Khorana AA. Identifying predictors for bleeding in hospitalized cancer patients: A cohort study. Thromb Res 2017; 158: 38-43
5 Browder T, Folkman J, Pirie-Shepherd S. The hemostatic system as a regulator of angiogenesis. J Biol Chem 2000; 275 (3): 1521-4
6 Nitori N, Ino Y, Nakanishi Y, et al. Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma. Clin Cancer Res 2005; (11): 2531-9
7 Han LY, Landen CN. Jr, Kamat AA, et al. Preoperative serum tissue factor levels are an independent prognostic factor in patients with ovarian carcinoma. J Clin Oncol 2006; (24): 755-61
8 Чехонин В. П., Шеин С. А., Корчагина А.А., Турина О. И. Роль VEGF в развитии неопластического ангио-генеза. Вестник РАМН 2012; (2): 23-34
9 Киселёв Л. П., Савицкая Т. В., Алейникова О. В. Факторы роста сосудистой сети в плазме и сыворотке крови у педиатрических пациентов с саркомами и незлокачественными заболеваниями опорно- двигательного аппарата. Онкопедиатрия 2016; 3 (2): 113-9
10 Петрищев H.H., Васина Л. В., Власов Т.Д. и др. Типовые формы дисфункции эндотелия. Клинико-лабораторный консилиум 2007; (18): 31-6.

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