Metabolic shifts in subjects with potential risk of primary osteoarthritis
Year: 2018, volume 14 Issue: №3 Pages: 511-514
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Belova S.V., Gladkova Е.М., Ulyanov V.Yu., Blinnikova V.V.
Organization:
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Belova S.V., Gladkova Е.М., Ulyanov V.Yu., Blinnikova V.V.
Organization:
Summary:
The Aim of the study was to estimate metabolic disorders in subjects with potential risk of primary knee osteoarthri-tis development. Material and Methods. The study included 27 patients: 10 men (37%), 17 women (63%) aged from 33 to 68 years, and 20 healthy people (8 men and 12 women). Traditional biochemical indexes characterizing certain metabolic aspects (total protein, urea, cholesterol, glucose, uric acid, amylase and bilirubin) were studied alongside with the assessment of articular cartilage state by the level of COMP (cartilage oligometric matrix protein), malondial-dehyde and ceruloplasmin. Results. In the course of our investigation we observed elevated COMP (Me=871,4 (792,2; 912,5)), malondialdehyde (Me=5,1 (4,7; 5,5)) and ceruloplasmin (Me=48,4 (41,2; 55,4)) levels. Conclusion. Negative metabolic shifts in the form of cartilage tissue metabolic disorders, activated lipid peroxidation and relative failure of body antioxidant system were observed in patients with potentially high risk of knee osteoarthritis without clinical manifestations of the disease.
Bibliography:
1 Anikin SG, Alekseeva LI. Chondroitin sulfate: the mechanisms of action, its efficacy and safety in the therapy of
osteoarthrosis. Modern Rheumatology Journal 2012; (3): 78-82
2 Nasonova VA, Mendel' Ol, Denisov LN,etal. Osteoarthrosis and obesity. Preventive Medicine 2011; 14 (1): 29-37
3 Milyutina NP, Korovets IV, Panina SB, et al. Glutathione-dependent enzymes in regulation blood and synovial fluid
redox-homeostasis in patients with osteoarthritis of the knee joint. Journal of Fundamental Medicine and Biology
2013; (3): 29-34
4 Lee AS, Ellman MB, Dongyao Y, et al. A current review of molecular mechanisms regarding osteoarthritis and
pain. Gene 2013; (527): 440-7
5 Olyunin YuA. Osteoarthritis: Current treatment principles and prerequisites for the development of personified
therapy. Modern Rheumatology Journal 2016; (3): 81-6
6 Rosa SC, Goncalves J, Judas F, et al. Impaired glucose transporter-1 degradation and increased glucose
transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human
cartilage. Arthritis Res Ther 2009; 11 (3): R80. Gubskiy Yul, Belenichev IF, Pavlov SV, et al. Toxicological effects of oxidative modification of proteins in various pathological conditions. Modern Problems of Toxicology 2005; (3): 20-6
8 Zhigalova OV, Balabina NM. The status of lipid peroxidation and antioxidant activity of blood in patients with
osteoarthritis. Siberian Medical Journal 2015; 135 (4): 41-3
9 Aleksenko EYu, Govorin AV. Parameters of lipid peroxidation, antioxidant protection in osteoarthrosis. Journal of
Volgograd State Medical University 2009; 4 (32): 33-6
10 Pinto S, Rao AV, Rao A. Lipid peroxidation erythrocyte antioxidants and plasma antioxidants in osteoarthritis
before and after homeopathic treatment. Homeoparty 2008; (97): 185-9
11 Deponte M. Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes. Bochim
BiophysActa 2013; (1830): 3217-66
12 Goldin A, Beckman JA, Schmidt AM, et al. Advanced glycation end products. Circulation 2006; 114 (6): 597-605
13 Verzijl N, DeGtoot J, Ben ZC, et al. Crosslinking by advanced glycation end products increases the stiffness of
the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for
osteoarthritis. Arhtritis Rheum 2002; 46 (1): 114-23.
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