Saratov JOURNAL of Medical and Scientific Research

Irritable bowel syndrome: epidemiological and pathogenetic aspects

Year: 2018, volume 14 Issue: №1 Pages: 53-60
Heading: Internal Diseases Article type: Review
Authors: Tikhonova Т.А., Kozlova I.V.
Organization: Saratov State Medical University

The literature review focuses on some epidemiological aspects, molecular-genetic predictors of irritable bowel syndrome formation, the role of psychosocial and infectious factors, low-grade inflammation, imbalance between neu-rotransmitters and cytokines, as well as changes in the intestinal microbiome in the development of irritable bowel syndrome.

1. Martynov Al, Shilov AM, Makarova IA. Irritable bowel syndrome: Pathogenetic mechanisms. Lechashchiy vrach 2010; (5)
2. Mayev IV, Cheryomushkin SV, Kucheryavy YuA. Irritable bowel syndrome: Roman criteria IV: On the role of visceral hypersensitivity and methods of its correction. Moscow: Prima Print, 2016; 64 p.
3. Drossman DA, Chang L, et al. Rome IV, functional gastrointestinal disorders, disorders of gut-brain interaction. Fourth, The Rome Foundation, Raleigh (NC), 2016
4. Sheptulin A.A., Vize-Khripunova M.A. Review of Rome IV criteria for the irritable bowel syndrome: are there any basic changes? The Russian Journal of Gastroenterology, Hepatology Coloproctology 2016; 26 (5): 99-103
5. Silivontchik NN, Pimanov SI. Irritable bowel syndrome (of the Rome IV consensus for functional gastrointestinal disorders). Lechebnoye delo 2017; 3 (55): 23-29
6. Agafonova NA. Post-infectious irritable bowel syndrome. Moscow: Forte print, 2013; 52 p.
7. Ballou SK, Keefer L. Multicultural considerations in the diagnosis and management of irritable bowel syndrome: a selective summary. Eur J Gastroenterol Hepatol 2013; (25): 1127
8. Ivashkin VT, Poluektova YeA. Irritable bowel syndrome: pathophysiological and clinical issues. The Russian Journal of Gastroenterology, Hepatology, Coloproctology 2015; (1): 4-16
9. Krogsgaard LR, Engsbro AL, Bytzer P. The epidemiology of irritable bowel syndrome in Denmark: A population-based survey in adults <50 years of age. Scand J Gastroenterol 2013; (48): 523
10. Osadchuk MA, Burdina VO. New pathogenic approaches to the treatment of irritable bowel syndrome, based on morphofunctional peculiarities of this pathology. Practical medicine 2014; 1 (77): 12-20
11. Fried М, Gwee КА, Khalif I, et al. Irritable Bowel Syndrome: a Global Perspective. World Gastroenterology Organization 2015; (9): 3-26
12. Shilankova SO. Combination of somatic and mental component in functional diseases of the gastrointestinal tract. Nauchnoye obozreniye. Meditsinskiye nauki 2016; (4): 116-119
13. Ivashkin VT, Shul'pekova YuO. Nervous mechanisms of pain sensitivity. The Russian Journal of Gastroenterology Hepatology, Coloproctology 2002; 12 (4): 16-21
14. Turko TV, Makhov VM. Irritable Bowel Syndrome. Russian Medical Journal 2006; (1): 52
15. Butorova LI, Tokmulina GM, Plavnik ТЕ, et al. Roman criteria for the IV syndrome of irritable bowel: the evolution of views on pathogenesis, diagnosis and treatment. Lechashchiy vrach 2017; (3)
16. Nemtsov VI. Irritable Bowel Syndrome (IBS): current understanding of etiopathogenesis and treatment. Lechashchiy vrach 2015; (6)
17. Agafonova NA, Popova YeV, Yakovenko ЕР, et al. The role of the intestinal microflora in the formation of irritable bowel syndrome (IBS) and IBS-like disorders: Questions of therapy. Pharmateca 2012; (2): 26-31
18. Pantyukhina AS. Comparative evaluation of drug and non-drug treatment for irritable bowel syndrome: PhD diss. Izhevsk, 2017; 139 p.
19. Plotnikova YeYU, Krasnova MV, Baranova YeN. Irritable bowel syndrome — a disease with many variables (some therapeutic aspects). Herald of Pancreatic Club 2015; (2): 41-50
20. Tsimmerman YAS. Irritable bowel syndrome: what is its true nature? Clinical Medicine 2014; (7):19-28
21. Kim HS, Lim JH, Park H, et al. Increased immunoendocrine cells in intestinal mucosa of postinfectious irritable bowel syndrome patients 3 years after acute Shigella infection-an observation in a small case control study. Yonsei Med2010; (J51): 45-51
22. Yakovenko EP, Ivanov AN, Agafonova NA, et al. Violation of the normal composition of intestinal bacteria: clinical significance and issues of therapy. Russian Medical Journal 2008; 10 (2): 41-46
23. Fadeyenko GD, Chirva OV. The irritable bowel syndrome and possibilities of its correction. Modern Gastroenterology 2013; 2 (70): 39-44
24. Barkhordari Е, Rezaei N, Mahmoudi М, et al. T-helper 1, T-helper 2, and T-regulatory cytokines gene polymorphisms in irritable bowel syndrome. Inflammation 2010; (33): 281-286
25. Kozlova IV Irritable Bowel Syndrome: new aspects of pathogenesis, diagnosis, flow forecasting. The Russian Journal of Gastroenterology, Hepatology, Coloproctology 2000; (3): 57-63
26. Tyakht AV, Kostryukova ES, Popenko AS, et al. Human gut microbiota community structures in urban and rural populations in Russia. Nature Communications 2013; 4 (2469)
27. Sheptulina AF, Ivashkin VT. Irritable bowel syndrome concept from the gut microbiom point of view. The Russian Journal of Gastroenterology, Hepatology, Coloproctology 2016; 26(6): 120-123
28. Tkach SM, Dorofeev АЕ, Rudenko MM. Dysbiosis and bacterial overgrowth syndrome at the irritable bowel syndrome: correction with the use of Saccharomyces boulardii CNCM I-745. Modern Gastroenterology 2016; 4 (90): 33-42
29. De Palma G. Transfer of anxiety and gut dysfunction from IBS patients to gnotobiotic mice through microibota transplatation. CDDW2014; (3): 238
30. Pyleris E, Giamarellos-Bourboulis EJ, Koussoulas B. Prevalence of small intestinal bacterial overgrowth in a greek cohort: relationship with irritable bowel syndrome. Gut 2010; (59): A 19
31. Kucheryavy YuA, Cheryomushkin SV, Mayevskaya YeA, et al. Interrelation of irritable bowel syndrome and bacterial overgrowth: is there any? The Russian Journal of Gastroenterology, Hepatology, Coloproctology 2014; (2): 5-14
32. Belmer SV Immunologic aspects of irritable bowel syndrome. Lechashchiy vrach 2016; (8)
33. Grigor'yev PYa, Yakovenko ЕР. Irritable bowel syndrome associated with dysbiosis. Consilium Medicum 2000; 2 (7)
34. Cynthia KY Cheung, Justin CY Wu. Genetic polymorphism in pathogenesis of irritable bowel syndrome. World J Gastroenterol 2014; 20 (47): 17693-8
35. Valverde-Villegas JM, Santos BP, Machado MB, et al. G2848A and T-1237C polymorphisms of the TLR9 gene and susceptibility to inflammatory bowel disease in patients from southern Brazil. John Wiley & Sons Ltd Tissue Antigens 2014; (83): 190-2
36. Kurbatova AA. Pathogenetic and clinical significance of the cytokines and claudine system in patients with irritable bowel syndrome: PhD abstract. Moscow, 2013; 25 p.
37. Beutheu-Youmba S, Belmonte LE, et al. The expression of the tight junction proteins, claudin-1, occludin and ZO-1 is redused in the co-Ionic mucosa of patients with irritable bowel syndrome. Gut 2009; 59 (11): 5-57
38. Cremon C, Gargano L, Morselli-Labate AM, et al. Mucosal immune activation in irritable bowel syndrome: gender-dependence and association with digestive symptoms. Am J Gastroenterol 2009; (104): 392-400
39. Osadchuk AM, Osadchuk MA, Balashov AV, et al. Pathogenetic aspects of clinical variants of irritable bowel syndrome from the viewpoint of disturbing the diffuse endocrine system and cell renewal of colonocytes. The Russian Journal of Gastroenterology, Hepatology, Coloproctology 2008; (1): 38-44
40. Sarsenbaeva AS, Ivanova EL, Burmistrova AL, et al. The character of morphological changes in the mucous membrane of the large intestine and the genetic polymorphism of IL-1Ra, IL-1 b, IL-4, TNF-a in patients with irritable bowel syndrome. Eksperimental'naya i klinicheskaia gastroenterologiia 2013; (8): 28-33
41. Sharova IA, Stashkevich DS, Evdokimov A, et al. Polymorphism of the genes of the main cytokines and the tolllike receptor 4 and the variability of irritable bowel syndrome in Russians of Chelyabinsk region. Nauchno-metodicheskiy elektronnyy zhurnal «Kontsept» 2017; (39): 3241-5
42. Semenova YeV, IvanovAV. The role of single nucleotide polymorphisms of a number of genes of innate immunity in the development of irritable bowel syndrome. Gastroenterology of Sanct-Petersburg 2017; (1): 30-41
43. Samsonov АА, Plotnikova YeYu, Borshch MV. Post-infectious irritable bowel syndrome is a special form of functional intestinal pathology. Lechashchiy vrach 2012; (7): 21-9
44. Karling Р, Danielsson A, Wikgren М, Del-Favero J, et al. The Relationship between the Val158Met Catechol-oMethyltransferase (COMT) Polymorphism and Irritable Bowel Syndrome. PLoS ONE | (18.12.2017)
45. Kozlova IV, Myalina YuN, Badieva OE. Clinical and diagnostic significance of the content of tissue neurotransmitters in functional and inflammatory bowel diseases. Molecular medicine 2015; (3): 8-13
46. Gusakova YeV. Non-pharmacological correction of the functional state of patients with irritable bowel syndrome: DSc abstract. Moscow, 2008; 47 p.
47. Trubina NV. Violations of neurohumoral regulation in pathogenesis, clinic and diagnosis of functional diseases of the gastrointestinal tract: PhD abstract. Volgograd, 2009; 25 p.
48. Yarmysh NV, Groznaya LN. Endothelial dysfunction and its regulatory factors. Bulletin of problems biology and medicine 2014; 3 (2): 37-43
49. Drossman DA. Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features, and Rome IV Gastroenterology 2016; 150 (6): 1262-79. USA
50. Filipovic B, Forbes A, Tepes B. Current Approaches to the Functional Gastrointestinal Disorders. Gastroenterol Res Pract 2017; 2017: 4957154
51. Lacy В E, Mearin F, Chang L, et al. Bowel Disorders Gastroenterology 2016; (150): 1393-1407. USA
52. Burulova OE, Kozlova IV, Myalina YuN. Irritable bowel syndrome as a biopsychosocial disease (review). Saratov Journal of Medical Scientific Research 2012; 8 (2): 232-23
53. Kozlova IV, Myalina YuN, Tikhonova ТА, et al. Psychological featuresof patients with functional and inflammatory bowel diseases. Saratov Journal of Medical Scientific Research 2014; 10 (1): 80-85
54. Kozlova IV, Myalina YuN, Tikhonova ТА, et al. Bowel diseases as a psychosomatic problem. In: European conference on innovations in technical and natural sciences. Vienna, 2014; p. 126-132
55. Kozlova IV, Myalina YuN, Tikhonova ТА, et al. Clinical and laboratory criteria in treatment efficiency estimation for patients with irritable bowel syndrome. Lechashchiy vrach 2016; (4): 125
56. Kozlova IV, Pakhomova AL. Modern patient of the gastroenterological profile: strokes to the clinical portrait. Eksperimental'naya i klinicheskaia gastroenterologiia 2015; 6 (118): 4-10
57. Myalina YuN, Kozlova IV, Tikhonova ТА, et al. Therapy of alarm disorders in syndrome of irritable intelligence Eksperimental'naya i klinicheskaia gastroenterologiia 2014; 5 (105): 70a
58. Tikhonova ТА, Kozlova IV, Myalina YuN. Some indicators of the "internal picture of the disease" in patients with diseases of the colon. Eksperimental'naya i klinicheskaia gastroenterologiia 2014; (2): 54a
59. Ganzin IV Investigation of the genesis of a psychosomatic symptom in irritable bowel syndrome. Klinicheskaya psikhiatriya i psikhofarmakoterapiya 2015; 19 (1): 26-33
60. Gataulina OV, Belova II, Demina El, et al. Personality deviations in irritable bowel syndrome. Gastroenterology of Sanct-Petersburg 2011; (2-3): M17-18
61. Kozlova YuA. Irritable Bowel Syndrome: Clinical Significance of Vegetative Status in the Refractory Course of the Disease: PhD abstract. Moscow, 2015; 25 p.
62. Kharchenko NV, Opanasyuk ND. The mechanisms of development and the methods of correction of irritable bowel syndrome. Modern Gastroenterology 2014; 6 (80): 68-75
63. Kugler ТЕ. Quality of life of patients with functional gastrointestinal diseases: are there differences? Lechebnoye delo 2015; 2 (42): 36-40
64. Morozova MA, Rupchev GYe, Alekseyev AA, et al. Dysphoric spectrum of emotional disorders at irritable bowel syndrome. The Russian Journal of Gastroenterology, Hepatology Coloproctology 2017; 27 (1): 12-22
65. Solomentseva ТА. Irritable bowel syndrome: the difficulties in diagnosis and treatment. Modern Gastroenterology 2016; 2 (88): 114-120
66. Yakovenko AV, Ivanov AN, Pryanishnikova AS, et al. Pathogenetic approaches in the treatment of irritable bowel syndrome. Lechashchiy vrach 2011; (7).

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