Saratov JOURNAL of Medical and Scientific Research

2015, volume 11

Clinical features of mastocytosis in children

Year: 2015, volume 11 Issue: №3 Pages: 439-441
Heading: Dermatovenerology Article type: Case report
Authors: Shustova О.А., Schnaider D.A., Morrison A.V., Sherstobitova K.Y.
Organization: Saratov State Medical University, SEH «Saratov regional dermatovenerologic dispensary»
Summary:

A case of cutaneous mastocytosis, relating to the rarely seen dermatoses, is presented in the study. The data of etiology, pathogenesis, clinical picture are generalize.

Keywords: clinic, etiology, mastocytosis, pathogenesis

Role of wax model museums in the teaching of dermatovenerology at medical universities of Russia and Europe

Year: 2015, volume 11 Issue: №3 Pages: 435-438
Heading: Dermatovenerology Article type: Author's opinion
Authors: Utz S.R., Zavyalov A.l., Yakupov I.A., Parkhomenko A.A.
Organization: Saratov State Medical University, The branch «Zelenograd» Moscow Scientific and Practical Center of dermatology and cosmetology of Moscow Health Department
Summary:

The article shows the history and the significance of use of wax masks in the process of visual teaching of dermatology and venereology for students of medical universities in Europe and Russia in the XIX-XX centuries.

Keywords: dermatology, venereology, wax masks, waxworks museum

About the clinical effectiveness of the far long-wave UV-therapy

Year: 2015, volume 11 Issue: №3 Pages: 431-434
Heading: Dermatovenerology Article type: Short message
Authors: Alipov N.V.
Organization: Saratov State Medical University
Summary:

Objective: to assess clinical efficiency and safety of using long wavelength ultraviolet therapy in children children and adolescents suffering from atopic dermatitis during exacerbation of the dermatosis. Materials and methods. The data about the usage of the far long-wave UV therapy in the treatment of 38 children suffering from atopic dermatitis. The 2nd group of patients (42 patients) received standard therapy with the use of the usual doses and methods of taking medication and did not differ from the first group by age of patients, duration and form of the disease. Results. All observed on the background of therapy was noted positive dynamics of the pathological process in the skin, however, patients of the 1st group were observed earlier (average 5-7 days) than in the 2nd group, resolution of the clinical manifestations of AD, which was confirmed by a significant decrease in SCORAD values (1,9±0,7; p

Keywords: atopic dermatitis, far long-wave UV therapy, narrow-band medium wave UV therapy, phototherapy, treatment

Pharmacoeconomics as an instrument of clinical pharmacology for optimization of pharmacotherapy

Year: 2015, volume 11 Issue: №3 Pages: 428-431
Heading: Dermatovenerology Article type: Review
Authors: Reshetko O.V., Lutsevich К.А., Nelyubova 0.I.
Organization: Saratov State Medical University
Summary:

The article presents pharmacoeconomics is an essential component of health technology assessment and the appraisal of medicines for use by patients. As a comparatively young discipline, its methods continue to evolve. Pharma-coeconomic analyses encompass cost — minimization, cost — utility, cost — benefit, and cost — effectiveness studies, providing essential information critical for optimization of pharmacotherapy, optimal health-care resource allocation and drug development success.

Keywords: pharmacoeconomics, economic efficiency, clinical pharmacology, analysis

The use of physical factors in the treatment of patients with microbial eczema

Year: 2015, volume 11 Issue: №3 Pages: 425-427
Heading: Dermatovenerology Article type: Review
Authors: Dobdina A.Yu.
Organization: Saratov State Medical University
Summary:

The article presents a review of the literature devoted to physical therapy of microbial eczema. The issues of the influence of various physical factors on the clinical manifestations and course of the given dermatosis are dicussed. The information about the new treatment of patients with microbial eczema is presented, using visible and infrared radiation transmitted through the water filtration.

Keywords: visible and infrared light passed through the water filter, therapy, physical factors, microbial eczema

Innovative medicines for treatment of psoriatic arthritis

Year: 2015, volume 11 Issue: №3 Pages: 423-425
Heading: Dermatovenerology Article type: Review
Authors: Levitan A.l., Reshetko O.V.
Organization: Saratov State Medical University
Summary:

The problem of effective treatment of psoriatic arthritis has not been solved yet. The search for new therapeutic options is very active in many directions. At the stage of clinical trials are drugs that block interleukin-17-a (secukinumab, ixekizumab, brodalumab), drugs that suppress interleukin-12 and interleukin-23 (ustekinumab). To modern means to ensure psoriatic arthritis include drugs that are inhibitors of small molecules orkinase pathways (apremilast, tofacitinib).

Keywords: inhibitors of interleukin-17-a, inhibitors of interleukin-12, inhibitors of interleukin-23, Janus-kinase inhibitor, psoriatic arthritis

On the relationship between innate and adaptive immunity in psoriasis

Year: 2015, volume 11 Issue: №3 Pages: 421-423
Heading: Dermatovenerology Article type: Review
Authors: Nikolashina О.Е., Bakulev A.L.
Organization: Penza Regional Clinical Center of specialized types of medical care, Saratov State Medical University
Summary:

There is an overview of the current literature data, which reflects the key aspects of the etiology and pathogenesis of psoriasis. A genetically determined, multifactorial nature of the dermatosis was displayed. There were summarized numerous domestic and foreign data on immunological (cellular, humoral, mediator, extravasation, angiogenesis) and non-immune mechanisms of genesis of psoriasis.

Keywords: adhesion molecule, cytokines, etiology, keratinocytes, pathogenesis

Problems and ways to improve the laboratory diagnosis of chlamydial infection

Year: 2015, volume 11 Issue: №3 Pages: 414-421
Heading: Dermatovenerology Article type: Review
Authors: Sultanakhmedov E.S., Utz S.R., Fyodorova V.A.
Organization: Saratov Scientific and Research Veterinary Institute of Federal Agency for Scientific Organizations, Saratov State Agrarian University named after N.I. Vavilov, Saratov State Medical University
Summary:

The review highlights the historical aspects and modern concepts of laboratory diagnosis of chlamydial infection. The studies on investigation of different strains of Chlamydia trachomatis performed in Russian Federation and abroad are summarized. The results of research of domestic and foreign scientists aimed at finding the perfect laboratory test for identification of C. trachomatis on the basis of molecular biological methods are analyzed and presented.

Keywords: Chlamydia trachomatis , chlamydial infection, laboratory diagnostics, molecular biological methods

Cytokine markers of the efficiency of correction of oxidative stress in patients with limited sclerodermia

Year: 2015, volume 11 Issue: №3 Pages: 410-414
Heading: Dermatovenerology Article type: Short message
Authors: Tlish M.M., Sorokina N.V.
Organization: Kuban State Medical University
Summary:

Objective: to improve treatment of patients with limited sclerodermia (LSD) by increasing efficiency and reducing the time of their treatment. Material and methods. The examination and treatment of 52 patients with circumscribed scleroderma were conducted. Two groups of these patients were formed with method of adaptive randomization. In the control group complex treatment was underwent according to the standards in this nosology. In the general group the patients additionally received antioxidant therapy. The course of treatment was 21 days in both groups. Results. Treatment results were evaluated in accordance with the dynamics of cutaneous pathological process and cytokine profile. In the course of treatment positive clinical dynamics in patients of the study group went faster and was accompanied by a more pronounced reduction in inflammatory activity in the blood serum. Conclusion. The results suggest that antioxidant therapy improves the efficiency and reduces the treatment time of patients with circumscribed sclerodermia.

Keywords: circumscribed sclerodermia, cytokines, oxidant stress

The combined application of biological therapy and methotrexate in case of escape phenomenon progressing

Year: 2015, volume 11 Issue: №3 Pages: 405-409
Heading: Dermatovenerology Article type: Short message
Authors: Ponich E.S., Kruglova L.S., Babushkin A.M.
Organization: BU Khanty-Mansi Autonomous District— Yugra «Khanty-Mansi clinical skin and venereologic dispensary»
Summary:

Aim: the study of the efficacy of methotrexate in patients with the "escape effect" during the ustekinumab therapy. Materials and Methods. The results of methotrexate at a dose of 15-20mg/week in treatment of 4 patients receiving biologic and developed "escape effect". Ustekinumab is used as a hypodermic injection at a dose of 45 mg for a body weight of a patient no more than 100 kg, and 90 mg of body weight over 100 kg, at the zero week, the 4th week and then every 12 weeks. Patients control meets the standard management of patients in biological therapy. Results. The study shows that in the case of the resistance progressing when applying preparations of biological therapy, methotrexate is useful at a dose of 15-20mg/week for up to 6 months. The combined use of biologic therapy and methotrexate in the treatment of patients with psoriasis vulgaris, "escape effect" contributes to the marked regression of clinical symptoms and allows to control the process long enough, which is confirmed by the dynamics of the index PASI, BRS and DLQI. The combined method is highly safe, as evidenced by the lack of inhibition of hematopoiesis, the normal level of hepatic transaminases and serum creatinine, which greatly improves patient compliance in this type of therapy. Conclusion. The article presents the data of the combined application of biological medication therapy (ustekinumab) and methotrexate for the treatment of patients with the common form of psoriasis vulgaris. In the case of the development of resistance of biological therapy recommended the appointment of methotrexate. The combined use of methotrexate and biologic therapy in the treatment of patients with psoriasis vulgaris contributes to marked regression of clinical symptoms and allows to control the process for a long time.

Keywords: biological therapy, BSA, methotrexate, PASI, psoriasis, quality of life, system therapy, ustekinumab