Saratov JOURNAL of Medical and Scientific Research

Pharmacometrics as an instrument of clinical pharmacology for optimization of drugs dosing regimens during pregnancy

Year: 2014, volume 10 Issue: №1 Pages: 199-203
Heading: Parmacology Article type: Review
Authors: Reshetko O.V., Lutsevich К.А.
Organization: Saratov State Medical University
Summary:

Changes in maternal physiology and metabolic during pregnancy influence pharmacokinetics and illustrate that standard adult dosing is likely to be incorrect during pregnancy. Different pharmacometric approaches are available for design and analysis of clinical studies during pregnancy. Physiologically-based pharmacokinetic (PBPK) model could be used to evaluate different dosing regimens for pregnant women and serves in predicting drug exposure and response at the personal level.

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