Saratov JOURNAL of Medical and Scientific Research

ММР and RHOA gene expression in persoms exposed to ionizing radiation

Year: 2013, volume 9 Issue: №4 Pages: 780-783
Heading: Genetics Article type: Original article
Authors: Mikhailov V.F., Zasukhina G.D., Shishkina A.A., Shulenina L.V.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

The purpose of the study is to investigate the mechanisms of MMP-7, -13, TIMP-2 and RhoA genes expression in blood cells after ionizing radiation exposure. Material and methods.Ne had examined blood samples from 27 healthy donors, 32 prostate cancer patients before and after radiotherapy, and 32 Chernobyl liquidators by qRT-PCR method. Result. Our results suggests that the expression of MMP-7, MMP-13 genes in prostate cancer patients with grade 2 (T2N0M0). Probably, these changes were associated with the tumor process development, but no with radiation therapy. RhoA level in blood of liquidators was decreased.

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