Saratov JOURNAL of Medical and Scientific Research

Effect of low-intensity electromagnetic radiation on structurization properties of bacterial lipopolysaccharide

Year: 2013, volume 9 Issue: №4 Pages: 637-640
Heading: Microbiology Article type: Original article
Authors: Brill G.E., Egorova А.V., Bugaeva I.О, Dubovitsky S.A., Vlaskin S.V.
Organization: Research and production firm “Telemak”, Russia, Saratov, Saratov State Medical University
Summary:

Purpose: to investigate the effects of low-intensity electromagnetic radiation on the process of dehydration self-organization of bacterial lipopolysaccharide. Materials and Methods. The method of wedge dehydration has been used to study the structure formation of bacterial lipopolysaccharide. Image-phases analysis included their qualitative characteristics, as well as the calculation of quantitative indicators, followed by statistical analysis. Results. UHF-Radiation (1GHz, 0,1 uW/cm2, 10 min) has led to the changes in the suspension system of the LPS-saline reflected in the kinetics of structure formation. Conclusion. 1 GHz corresponds to the natural frequency of oscillation of water clusters and, presumably, the effect of UHF on structure of LPS mediates through the changes in water-salt environment. Under these conditions, properties of water molecules of hydration and possibly the properties of hydrophobic and hydrophilic regions in the molecule of LPS, which can affect the ability of toxin molecules to form aggregates change. Therefore the lipopolysaccharide structure modification may result in the change of its toxic properties.

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