Comparative assessment of efficacy of different methods of treatment of pancreatogenic diabetes mellitus in alcoholic and biliary forms of chronic pancreatitis

Aim: the study was devoted to the analysis of efficacy of different methods of treatment of pancreatogenic diabetes mellitus (DM) in alcoholic and biliary forms of chronic pancreatitis (CP). Material and methods. We have observed 86 patients with CP and first diagnosed DM. The assessment of carbohydrate metabolism compensation via HbA1 с level was done using analyzer IMX «Abbot» (USA). Results. At the 1st step of DM treatment we recommended the lifestyle modification and usage of creon 30-60.000 units daily. At the 2d step of treatment if necessary we added glyclazide. Conclusion. We have detected that irrespective of duration of alcoholic form of CP in case of subsequent DM development the lifestyle modification together with replacement ferment therapy in 90% of cases were non-effective. In the result of the research it was established, in case of 3 and more relapses per year in alcoholic form of CPthe probability of achievement of target HbA1 с level in complex with lifestyle changes and replacement ferment therapy was twice low, in connection with that fact the indication of oral anti-diabetic agents became necessary.