Saratov JOURNAL of Medical and Scientific Research

The analysis of transition probability of monofocal clinically isolated syndrome to clinically defnite multiple sclerosis

Year: 2012, volume 8 Issue: №2 Pages: 432-435
Heading: Neurology Article type: Original article
Authors: Zakharov A.V., Poverennova I.E., Khivintseva E.V., Greshnova I.V., Gendullina E.A.
Organization: Samara State Medical University

The goal of the research is to investigate the frst attack of demyelinated disease with an affection of one of functional systems. To assess the factors affecting the rate of transition monofocal clinically isolated syndrome (CIS) into a reliable multiple sclerosis. The structure of monofocal CIS was studied in case of 102 observations. The conversion of monofocal CIS in clinically defnite multiple sclerosis (CDMS) was retraced. The results of clinical and instrumental methods (magnetic resonance imaging — MRI and multimodal evoked potentials — MEP) were studied. Clinical and instrumental identifed markers of high transition probability monofocal CIS to CDRS were found. Early age of CIS formation and a large number of demyelination foci on MRI are the risk factors for the development to CDRS.

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