Saratov JOURNAL of Medical and Scientific Research

EXPERIMENTAL STUDY OF THE ANTIHYPOXIC ACTIVITY OF NEW PHYSIOLOGICALLY COMPATIBLE ANTIOXIDANTS ON THE MODELS OF ACUTE HEMIC AND HISTOTOXIC HYPOXIA

Year: 2007, volume 3 Issue: №1 Pages: 99-100
Heading: Physiology and Pathophysiology Article type: Short message
Authors: N.P. Katunina, M. P. Katunin, E. V. Afonina, V. E. Novikov, E. A. Parfenov
Organization: Bryansk State University
Summary:

There is a complex composition of cuprum, pQ-1032 in cipher, revealed among 13 new physiologically compatible antioxidants (PCAO). This composition with the range of effective doses (10, 25, 50, and 100 mg/kg) and the degree of antihypoxic activity (26-36% increase in the life interval of mice) considerably exceeds other studied substances and well-known antihypoxants Emoxipine, Etomerzolum, Mexidolum, Nooglutilum, Natrii oxibutyras under acute hemic and histotoxic hypoxia. pQ-1032 may be recommended for further study and its possible application as an antihypoxant in clinics.

Keywords: antioxidant

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