Saratov JOURNAL of Medical and Scientific Research

№1, 2007, volume 3

PHARMACOLOGICAL CORRECTION OF PHYSICAL EFFICIENCY AFTER HYPERTHERMIC INFLUENCE

Year: 2007, volume 3 Issue: №1 Pages: 103-104
Heading: Physiology and Pathophysiology Article type: Short message
Authors: I.V. Ilyina, N.N. Samoilov, E.A. Parfenov
Organization: Bryansk State University
Summary:

Physical efficiency (PE) of mice under normal conditions was being increased with the help of 10 substances out of 20 physiologically compatible antioxidants (PCAO) under study and with the help of 5 of them after hyperthermic influence. The greatest effect was produced by the derivative of ascorbic acid pQ-461 in cipher. This derivative with the range of effective doses (1 -50 mg/kg) and actoprotector activity (22- 74% increase in PE) considerably exceeds other studied substances and actoprotector Bemithylum. The composition pQ-461 may be recommended for further study as a long-range thermoprotector.

Keywords: physical efficiency

THE INFLUENCE OF PHENYL-ETHYL-SUBSTITUTED DERIVATIVES OF 3-OXIPYRIDINE ON THE LIFE INTERVAL OF MICE UNDER ACUTE HYPOXIA WITH HYPERCAPNIA AND ACUTE HYPOBARIC HYPOXIA

Year: 2007, volume 3 Issue: №1 Pages: 100-103
Heading: Physiology and Pathophysiology Article type: Short message
Authors: N.P. Katunina, M.P. Katunin
Organization: Bryansk State University
Summary:

The subject of our study was the influence of 22-phenyl-ethyl-substituted derivative of 3-oxipyridine (3-OP) and 5 nedicines having antihypoxic and/or antioxidant characteristics (Mexidolum, Emoxipine, Etomerzolum, Nooglutilum, Natrii xibutyras) on the life interval of mice under acute hypoxia with hypercapnia (AHwHc) and acute hypobaric hypoxia (AHBH). he antihypoxic influence of the combinations is revealed to depend on their chemical structure, dose and model of acute ypoxia. The life interval of mice was being increased with the help of6 phenyl-ethyl-substituted derivatives of 3-OP under HwHc and 5 derivatives underAHBH. The composition CK-131 in cipher with the range of effective doses (50-200 mg/kg) nd antihypoxic activity (30-120 % increase in the life interval of mice) considerably exceeds other studied substances and ledicines in comparison Mexidolum, Emoxipine, Nooglutilum, Etomerzolum, Natrii oxibutyras under AHwHc and AHBH. The omposition CK-131 may be recommended for further study as a long-range antihypoxant.

Keywords: antioxidant

EXPERIMENTAL STUDY OF THE ANTIHYPOXIC ACTIVITY OF NEW PHYSIOLOGICALLY COMPATIBLE ANTIOXIDANTS ON THE MODELS OF ACUTE HEMIC AND HISTOTOXIC HYPOXIA

Year: 2007, volume 3 Issue: №1 Pages: 99-100
Heading: Physiology and Pathophysiology Article type: Short message
Authors: N.P. Katunina, M. P. Katunin, E. V. Afonina, V. E. Novikov, E. A. Parfenov
Organization: Bryansk State University
Summary:

There is a complex composition of cuprum, pQ-1032 in cipher, revealed among 13 new physiologically compatible antioxidants (PCAO). This composition with the range of effective doses (10, 25, 50, and 100 mg/kg) and the degree of antihypoxic activity (26-36% increase in the life interval of mice) considerably exceeds other studied substances and well-known antihypoxants Emoxipine, Etomerzolum, Mexidolum, Nooglutilum, Natrii oxibutyras under acute hemic and histotoxic hypoxia. pQ-1032 may be recommended for further study and its possible application as an antihypoxant in clinics.

Keywords: antioxidant

CONCEPTION OF THE POPULATION POLICY OF THE RUSSIAN FEDERATION TILL 2015

Year: 2007, volume 3 Issue: №1 Pages: 95-98
Heading: Sociology of Medicine Article type: Author's opinion
Authors: O.S. Efremova
Organization: Saratov National Research University n.a. N. G. Chernyshevsky
Summary:

The present-day aspects of the population policy of the Russian Federation have been examined, the reasons of increased depopulation established: low fertility (birth rate), high mortality, migration, lack of social setting. It is ascertained, that the main tasks of the population policy of the RFare: improvement of the population health and life interval, including state of health of children and teenagers, forming of the healthy life-style, increasing of social living standard. The conception of the population policy of the Russian Federation has been analyzed and the priority directions of its realization worked out.

Keywords: population policy

NEW ASPECTS FOR OPTIMISATION OF SURGICAL TREATMENT OF DISCOGENIC ALGETIC SYNDROMES IN PATIENTS WITH LUMBAR OSTEOCHONDROSIS

Year: 2007, volume 3 Issue: №1 Pages: 92-94
Heading: Traumatology and Orthopedics Article type: Original article
Authors: V.V. Ostrovskiy, I.A. Norkin, V.G. Ninel, V.N. Ivanchenkо
Organization: Saratov Scientific Research Institute of Traumatology and Orthopedics
Summary:

Results of surgical treatment of intervertebral disk herniations in 58 patients with discogenic algetic syndromes are giver in the article. Introduction of drug compound through the catheter placed in the epidural cavity with direct electrostimulatior of affected spinal nerve roots optimize the results of treatment in 92,8% of patients after repeated surgery.
Key words: intervertebral disk herniations, pain syndromes of spinal nerve roots, epidural application of drugs, direc, electrostimulation of spinal nerve roots.

Keywords: ostheochondrosis

EFFICIENCY OF USADE OF MAGNETOTHERAPY IN TREATMENT DIABETIC POLYNEUROPATHY IN CHILDREN

Year: 2007, volume 3 Issue: №1 Pages: 88-91
Heading: Pediatrics Article type: Original article
Authors: N.V.Bolotova, S.V.Hudoshina, U. M. Raygorodskiy
Organization: Saratov State Medical University
Summary:

The clinical data on application of magnetotherapy in treatment of diabetic peripheral polyneuropathy in 75 children (40 girls, 35 boys) of 7 - 10,5 y.o. with diabetes mellitus I type. 30 patients got the correction ofglycemia level. 30 children received with correction of a carbohydrate exchange of therapy running pulse magnetic field in a pulse mode with an induction of a field 45mTI and frequency of 10-16 Hz, appointed to area of shins. The rest 15 children received effect placebo. The usage of magnetic field of the specified parameters, with direction of field along a neurovascular bunch, allowed to increase conductivity of peripheral nerves in 1,5-2 fold with compared start values during one course of magnetotherapy

Keywords: pediatrics

THE CIRCULATION OF CASES OF ILLNESS BY CHILDREN'S CEREBRAL PARALYSIS IN SARATOV

Year: 2007, volume 3 Issue: №1 Pages: 84-86
Heading: Neurology Article type: Original article
Authors: Sholomov I.I., Alekseeva G.Yu.
Organization: Saratov State Medical University
Summary:

The analysis of statistical indexes of the activity of the children's neurologic service of Saratov in 2005 is represented. It s established that the cases of illness of CCP are higher in Volzhskey and Zavodskoy districts of Saratov. The direct relatic -between maximal values of load of the children's population on regular unity of the neuropathologist and predominance z -the heavy forms of the CCP is detected.

Keywords: pediatrics

WAY AND OPPORTUNITIES INTRAOPERATION CONTRASTIHG OF NERVOUS TRUNKS IN EXPERIMENT

Year: 2007, volume 3 Issue: №1 Pages: 80-83
Heading: Traumatology and Orthopedics Article type: Original article
Authors: D.K.Dzumagishiev, I.A.Norkin, R.P.Gorskov, V.G.Ninel
Organization: Saratov Scientific Research Institute of Traumatology and Orthopedics
Summary:

The way of artificial contrastment of peripheral nerves by non ionic water-soluble contrasts «Omnipaque-ЗОО» and «Ultravist-ЗОО», has shown high informaticy and simplicity of performance is developed in experiment. Contrast substance entered under epineuria of a nerve trunk to degree of hard filling ofepineural tubes and x-ray pictures performers. Experimenta researches have shown, that using of non-ionic contrast substance «Omnipaque-ЗОО» and «Ultravist-ЗОО» have low histitoxicit. in relation to tissues of peripheral nerves.

Keywords: surgical tactics

EXPERIMENTAL GROUNDS OF THE USAGE OF RETINALAMIN IN THE TREATMENT OF THE PARTIAL OPTIC ATROPHY

Year: 2007, volume 3 Issue: №1 Pages: 77-79
Heading: Ophtalmology Article type: Original article
Authors: Kamenskikh Т.G., Bashkatov A.N., Tuchin V.V., Genina E.A.
Organization: Saratov State Medical University
Summary:

Purpose: to study the sclera permeability as the most significant tissue barrier in the local application of medicines in ophthalmology for Retinalamin in vitro. Materials and methods. 23 rubbit's sclera samples were taken for the research in vitro. The water solution of Retinalamin has been tested too. The radiation reflected from sclera has been controlled by the system of receiving fibers of fiber optics probe and has been registered by optical multichannel analyzer (LESA- 5). Results: The experimental research makes it possible to assume that the full penetration of Retinalamin through sclera after the parabulbar injection lasts 3 hours.

Keywords: treatment

SARCOIDOSIS: CONTEMPORARY DISEASE COURSE AND VISCERAL INJURY

Year: 2007, volume 3 Issue: №1 Pages: 73-76
Heading: Internal Diseases Article type: Original article
Authors: E.Yu.Ponomaryova, P.V.Fokina, A.P.Rebrov
Organization: Saratov State Medical University
Summary:

40 case histories of patients with systemic sarcoidosis have been studied in order to evaluate the clinical peculiarities of the disease course. We have shown the chronic and systemic course of the disease that needs to be taken into account in the diagnostic process and during the treatment. The character of the lung and other inner organ sarcoid injury has been given in the work

Keywords: visceral pathology