Саратовский научно-медицинский ЖУРНАЛ

Адипокины и их возможная роль в ожирении и сахарном диабете 2-го типа

Год: 2018, том 14 Номер: №2 Страницы: 201-206
Рубрика: Эндокринология Тип статьи: Обзор
Авторы: Кузнецова Л.А., Шпаков А.О.
Организация: ФГБУН «Институт эволюционной физиологии и биохимии им. И. М. Сеченова Российской Академии Наук»
Резюме:

Жировая ткань является эндокринным органом, секретирующим полипептидные факторы, называемые ади-покинами, которые участвуют в регуляции пищевого поведения, метаболических, эндокринных и воспалительных процессов и инсулиновой чувствительности. При ожирении и сахарном диабете 2-го типа (СД2) продукция адипокинов и активность их сигнальных путей меняются, что играет важную роль во взаимосвязях между ожирением, инсулиновой резистентностью и СД2. В обзоре проанализированы данные (по типам ожирения) о продукции жировой тканью адипокинов с диабетогенными (лептин, висфатин, кемерин, васпин, апелин, резистин) и антидиабетическими (адипонектин, оментин) свойствами, а также сведения о возможной роли адипокинов в развитии ожирения и СД2.

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