Саратовский научно-медицинский ЖУРНАЛ

Оценка эффективности применения циклоспорина при псориазе

Год: 2017, том 13 Номер: №3 Страницы: 673-678
Рубрика: Дерматовенерология Тип статьи: Обзор
Авторы: Круглова Л. С, Понич Е. С, Осина А.В., Грязева Н.В.
Организация: ФГБУ ДПО «Центральная государственная медицинская академия» УД Президента РФ
Резюме:

Представлен обзор рандомизированных исследований, в которых приняли участие пациенты с тяжелым псориазом, показавших, что после 10-12 недель монотерапии циклоспорином отмечается снижение Индекса распространенности и тяжести псориаза (PASI). После достижения клинической ремиссии должно быть принято решение о постепенном снижении дозы циклоспорина до минимальной эффективной дозы либо же о полной отмене приема препарата. Одновременное применение циклоспорина и UVB на данный момент широко не изучено. Комбинированное применение метотрексата и циклоспорина успешно используется в терапии ревматоидного и псориатического артрита. Комбинированный прием циклоспорина и системных биологических препаратов должен быть использован в исключительных случаях тяжелых форм псориаза, не поддающихся другим видам лечения, и только в течение ограниченного времени.

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