Саратовский научно-медицинский ЖУРНАЛ

Фармакометрика как инструмент клинической фармакологии для оптимизации режима дозирования лекарственных средств во время беременности

Год: 2014, том 10 Номер: №1 Страницы: 199-203
Рубрика: Фармакология Тип статьи: Обзор
Авторы: Решетько О.В., Луцевич К.А.
Организация: ФГБОУ ВО Саратовский ГМУ им. В.И. Разумовского Минздрава России
Резюме:

Изменения физиологических и метаболических процессов во время беременности оказывает влияние на фармакокинетику лекарственных средств, иллюстрируя возможность некорректности стандартного режима до-
зирования во время беременности. Различные фармакометрические подходы доступны для дизайна и анализа клинических исследований во время беременности. Физиологически обоснованная фармакокинетическая (physiology-based pharmacokinetic, РВРК) модель может быть использована для оценки различных режимов дозирования ЛС у беременных женщин и полезна в предсказании лекарственного воздействия и ответа на него на индивидуальном уровне.

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